How to Choose the Right Weight Loss Medication: Comparing the Cost and Effectiveness of Qsymia, Contrave, and GLP-1 Options Like Semaglutide and Tirzepatide
If you’re exploring prescription options for weight loss, it helps to know there are several effective paths. The field has grown quickly, with proven oral medications like Qsymia and Contrave, as well as newer injectables such as Ozempic, Wegovy, and Zepbound.
Each medication works differently. Some reduce appetite, others improve blood sugar control, and some do both. Most people want to know two things: how well they work and how much they cost.
Those are important questions because pricing can be a barrier and insurance coverage varies. Some plans won’t cover weight loss medications at all. Others may require trying older, lower-cost drugs before approving newer options, or they may limit coverage to specific situations. Effectiveness also varies from person to person, and every option comes with potential side effects.
This guide looks at how today’s most common medications perform in the real world and what you can expect to pay with or without insurance. Whether you’re just getting started or considering a switch, this overview will help you understand your options and have a more informed conversation with your clinician.
Qsymia and Contrave at a Glance
Qsymia is a combination of phentermine (an appetite suppressant) and topiramate (which helps reduce cravings and promotes fullness). The two together can lead to meaningful weight loss for many patients.
Contrave combines bupropion and naltrexone. Bupropion can reduce appetite, while naltrexone helps curb cravings by acting on the brain’s reward pathways. This pairing is often helpful for people who struggle with emotional or habit-driven eating.
Both medications are FDA-approved for chronic weight management and work best when paired with nutrition, activity, and lifestyle changes. In clinical use, many patients see about 5–10% total body weight loss over time with steady adherence and behavioral support.
Where GLP-1 Medications Fit (Semaglutide and Tirzepatide)
GLP-1 receptor agonists (e.g., semaglutide) and dual GIP/GLP-1 agonists (e.g., tirzepatide) mimic gut hormones that regulate appetite, gastric emptying, and insulin response. Brand names you’ll recognize include Ozempic and Wegovy (semaglutide) and Zepbound (tirzepatide).
Semaglutide has shown substantial weight loss in clinical trials by reducing hunger and helping people feel full sooner and longer.
Tirzepatide activates both GIP and GLP-1 pathways and has produced even greater average weight loss in head-to-head analyses, making it one of the most effective medications available today.
Metformin as an Adjunct
Metformin is an older, inexpensive medication primarily used for type 2 diabetes and insulin resistance. It’s not FDA-approved for weight loss, but it is often used off-label as a helpful add-on, especially in patients with prediabetes, insulin resistance, or PCOS. On average, metformin produces modest weight loss of about 2–3% of body weight over 6–12 months (roughly 4–6 pounds for a 200-pound adult), with some patients doing better when insulin resistance is a major driver of weight gain. It’s generally well tolerated and low cost, though gastrointestinal side effects (nausea, loose stools) can occur, especially at higher doses or with rapid titration. Because it’s generic and affordable, metformin can be a practical “foundation” or adjunct alongside lifestyle changes and, when appropriate, other weight-loss medications.
Comparing Costs and Effectiveness
When choosing a weight loss medication, it is important to understand the balance between cost and effectiveness. This section will provide a detailed comparison of the financial and weight loss expectations of different obesity medications.
Price Breakdown of Options
The cost of weight loss medications can vary significantly, affecting accessibility and long-term use. Here, we break down the estimated monthly costs for some popular options:
|
Medication |
Estimated Monthly Cost |
|
|---|---|---|
|
Qsymia |
$98, less with insurance coverage |
|
|
Contrave |
$99, less with insurance coverage |
|
|
Semaglutide (Retail Pricing) |
$499 (Cash), less with insurance coverage |
|
|
Tirzepatide (Retail Pricing) |
$499 (Cash), less with insurance coverage |
|
|
Phentermine |
$15-25 with GoodRx |
|
|
Metformin |
$4-20 with insurance or discount programs |
|
Prices can fluctuate based on insurance coverage. Drugs.com provides a comparative analysis, helping you assess which medication fits your budget.
It is always a good idea to check GoodRx for potential savings as the coupons can sometimes significantly reduce costs.
Effectiveness and Success Rates
The effectiveness of these weight loss medications can be compared by reviewing the clinical trials and data available. Generally, these medications are most successful when combined with lifestyle changes such as diet and exercise. Here’s a quick comparison based on reported weight loss percentages:
|
Medication |
Average Weight Loss (%) |
|---|---|
|
Metformin |
2-5% |
|
Phentermine |
4-9% |
|
Qsymia |
5-10% |
|
Contrave |
5-9% |
|
Semaglutide |
15-20% |
|
Tirzepatide |
20-25% |
These percentages reflect average outcomes and may vary. For comprehensive research, PMC offers detailed studies on these medications’ effectiveness.
Combining medication with healthy lifestyle changes remains essential. Drugs.com provides useful comparisons to help evaluate which option aligns with your weight loss goals.
Personalized Weight Loss Programs at Ascent TRT & Weight Loss
At Ascent TRT & Weight Loss in Burleson, TX, we understand that every patient’s weight loss journey is unique. Our experienced medical team specializes in prescription weight loss medications including Semaglutide, Tirzepatide, Qsymia, Contrave, Metformin, and Phentermine. We take the time to evaluate your complete health profile, including any conditions like diabetes, PCOS, or metabolic syndrome, to recommend the most effective medication for your specific situation.
When you choose Ascent TRT & Weight Loss for your weight loss program, you’ll receive:
Comprehensive Medical Evaluation: We assess your health history, current medications, and weight loss goals to create a personalized treatment plan.
Affordable Weight Loss Options: We offer competitive pricing on all weight loss medications and can help you navigate insurance coverage or find cost-saving alternatives to fit your budget.
Ongoing Support and Monitoring: Regular follow-up appointments ensure your medication is working effectively and allows us to make adjustments as needed for optimal results.
Convenient Burleson Location: Serving patients throughout the greater Fort Worth area with easy access to quality weight loss care.
Whether you’re interested in the newer GLP-1 medications like Semaglutide and Tirzepatide, or more budget-friendly options like Metformin and Phentermine, our team will help you find the right solution. We believe in sustainable weight loss that combines effective medication with lifestyle changes for long-term success.
Ready to start your weight loss journey? Contact Ascent TRT & Weight Loss in Burleson, Texas today to schedule your consultation and discover which prescription weight loss medication is right for you. You can also book a free consultation here.